Projektnews Rosetta@home: Project News May 10, 2016

[P3D-Bot]

We've come out with a breakthrough paper in Science titled 'De novo designof protein homo-oligomers with modular hydrogen-bond network-mediatedspecificity'.This is an exciting and significant breakthrough for de novo proteindesign. A particular challenge for current protein design methods has beenthe accurate design of polar binding sites or polar binding interfaces,both of which require hydrogen bonding interactions. Hydrogen bondnetworks are governed by complex physics and energetic coupling, thatuntil now, could not be computed within the scope of design. Thecomputational method described in this paper, HBNet, now provides ageneral method to accurately design in hydrogen bond networks. This newcapacity should be useful in the design of new enzymes, proteins that bindsmall molecules, and polar protein interfaces. Thanks Rosetta@homecommunity for your participation and help!The PDF of this article can be found herehttps://www.bakerlab.org/wp-content/uploads/2016/05/680.full_.pdf. Anarticle on this work was also published in Geekwire http://www.geekwire.com/2016/uw-researchers-add-new-twists-protein-designs.

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