Projektnews Folding@Home: Simulating protein dynamics to find binding-competent states

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Mutation to the tumor-suppressor protein p53 is a common feature in most cancers. MDM2–a protein whose job it is to downregulate p53 via their direct binding interaction–has therefore become a prime target for cancer therapeutics. Normally, a small helical region of p53 binds the MDM2 receptor site, but if a molecule with a similar shape [...]

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